Whakaahuatanga Poto:
Te nama CAS:472-15-1
tātai rāpoi:C30H48O3
taimaha rāpoi:456.71
Hanganga matū:
| Nga korero taketake | |
| ingoa hua | Te waikawa Betulinic |
| Kōeke | Koeke Pharma |
| Te ahua | He ma, he ma ranei |
| Te whakamatautau | 98% |
| Te ora papa | 2 tau |
| Te takai | 25kg/pahū |
| Tikanga | Pumau, engari whakamatao te rokiroki. He hotokore ki te kaha o te oxidizing agents, konupūmā gluconate, barbiturates, konupora pūkawa ngāwha, phenytoin, B rōpū konutai huaora. |
Whakaahuatanga
Ko te waikawa Betulinic (472-15-1) he Lupane triterpenoid maori mai i te rakau birch ma (Betula pubescens). Ka whakakorikori i te apoptosis i roto i nga momo rarangi pūtau.1 Induces mitochondrial permeability transition pore opening.2 ?Acts as a chemosensitizer for anticancer drug treatment in chemoresistant colon cancer cell lines.3 Cell permeable.
Whakamahi
Ko te Waikawa Betulinic he triterpenoid pentacyclic taiao. Ko te Waikawa Betulinic e whakaatu ana i nga mahi anti-inflammatory and anti-HIV. Ko te Waikawa Betulinic he whakakorikori i te apoptosis i roto i nga pūtau puku ma te whakahohe tika i te ara mitochondrial o te apoptosis ma te p53- me te CD95-motuhake. Kei te whakaatu hoki a Betulinic Acid i te mahi agonist TGR5.
Ko te waikawa Betulinic (BetA) kua whakamahia:
1.ki te whakamatautau i ona paanga hei kaikawe parepare ki te huaketo Dengue (DENV).
2.hei aukati i te pūmua here huānga sterol (SREBP) hei pehi i te paopaotanga lipid me te tipu o nga pūtau mate pukupuku kirikiri (ccRCC).
3.hei maimoatanga ki te whakamatautau i ona ahuatanga anti-tumor mo te oranga o nga pūtau me nga whakamatautau mate apopototic cell i roto i nga tauira myeloma maha.
Rangahau mo te mate pukupuku
Ko tenei puhui he triterpene pentacyclic i riro mai i nga momo Betula me Zizyphus, e whakaatu ana i te cytotoxicity ki nga pūtau melanoma tangata (Shoeb2006). Ka whakaputahia e ia nga momo hāora tauhohenga, ka whakahohe i te MAPK cascade, inhibitstopoisomerase I, inhibits angiogenesis, modulates pro-growth transcriptionalactivators, modulates the activity of aminopeptidase-N, and there inducesapoptosis in cancer cells (Desai et al. 2008; Fulda 2008).
Mahi Koiora
Triterpenoid taiao e whakaatu ana i te mahi anti-HIV me te mahi antitumor. Ka whakatairanga i te hanga o nga momo hāora reactive (ROS) me te whakahohe i te NF- κ B. Ka whakaatuhia te mahi agonist TRG5 (EC 50 = 1.04 μ M).
Nga Mahi Biochem/physiol
Ko te waikawa Betulinic, he triterpene pentacyclic, ka whakakorikori i te apoptosis i roto i nga pūtau puku ma te whakahohe tika i te ara mitochondrial o te apoptosis ma te p53- me te CD95-motuhake.
