Whakaahuatanga Poto:
tau CAS:51322-75-9
tātai rāpoi:C9H8ClN5S
te taumaha ngota:253.71
Hanganga matū:
| Nga korero taketake | |
| ingoa hua | Tizanidine |
| Kōeke | Koeke Pharma |
| Te ahua | Paura ma |
| Te whakamatautau | 99% |
| Te ora papa | 2 tau |
| Te takai | 25kg/pahū |
| Tikanga | Rokiroki ki te -20°C |
Whakahuahua
Ko te Tizanidine he imidazoline e rua hauota heterocyclic pentene pärönaki. He rite te hanganga ki te clonidine. I te tau 1987, i whakarārangitia tuatahitia ki Finland hei kaiwhakawhanau agonist adrenalin α2. I tenei wa, ka whakamahia hei whakangawari uaua i roto i te whare haumanu. Ka taea te whakamahi ki te rongoa i nga uaua mamae mamae, penei i te mamae o te hope o te kaki me te torticollis. Ka taea hoki te whakamahi ki te rongoa i te mamae i muri i te mahi, penei i te kopae kopae me te mate rewharewha. Ka puta mai i te ankylosis o nga mate neurological, penei i te sclerosis maha, te myelopathy roa, te aitua cerebrovascular me te aha atu.
Mahi
Ka whakamahia ki te whakaiti i te taumahatanga o te uaua o te koiwi, te momi uaua me te myotonia na te whara o te roro me te taurakira, te whakaheke toto, te encephalitis me te sclerosis maha.
Pharmacology
Ka whakaitihia te tukunga o nga waikawa amino whakahihiko mai i nga interneuron me te aukati i te mahi synaptic maha e pa ana ki te uaua o te uaua. Kaore tenei hua e pa ki te whakawhitinga o te neuromuscular. He pai te whakamanawanui. He whai hua mo nga uaua mamae whakapeka me te ankylosis mau tonu i ahu mai i te taurakira me te roro. Ka taea e ia te whakaiti i te aukati o te neke haere, te whakaheke i te mokowhiti me te clonus, me te whakanui ake i te kaha o te nekehanga tuuao.
Whakamahinga
Ko te Tizanidine kua tapaina, he tikanga mo te whakamahi hei paerewa o roto mo te inenga o Tizanidine ma te GC-, LC-papatipu spectrometry ranei. Ka taea e Tizanidine te whakamahi rongoa hei aukati protease matua SARS-CoV-2.
Whakamahi Haumanu
Ko te Tizanidine he agonist adrenergic α2 receptor agonist e whakamahia ana ki te rongoa i nga ahuatanga o te mokowhiti uaua, penei i te sclerosis maha.
Te tikanga mahi
Ko te Tizanidine he taarua whakangawari uaua o te clonidine e whakaaetia ana hei whakaiti i te mokowhiti e pa ana ki te whara o te roro, o te taurakira. Ko tana tikanga mo te whakaheke i te mokowhiti e tohu ana i te aukati presynaptic o nga neuron motopaika i teα2-adrenergic pae fariiraa, whakaiti i te tuku o excitatory waikawa amino me te inhibiting ara ceruleospinal facilitatory, na hua i roto i te whakaiti i roto i te spasticity. Ko te Tizanidine he hautanga iti noa iho o te mahi antihypertensive o te clonidine, tera pea na te mahi i tetahi roopu-iti kua tohua.α2C-adrenoceptors, e ahua nei te kawenga mo te mahi analgesic me te mahi antispasmodic o te imidazolineα2-agonists(20).
